Effect of Oral Administration of Aqueous Leaves Extracts of Euphobia Lateriflora (Schum and Thonn) On Liver and Kidney Function in Rats

The effect of administration of graduated dose of aqueous leaf extract of Euphobia lateriflora on ALT, AST, ALP, bilirubin, total protein, creatinine and urea was determined to acertain the toxic effect of the extract on the liver and kidney. Significantly lower levels of AST and urea (p < 0.05) were observed in group administered with 100mg/kg leaf extract. There was no significant difference (p > 0.05) in ALT, ALP and levels of total protein in group administered with 100mg/kg aqueous extract and also ALT, AST, ALP and levels of bilirubin, total protein, creatinine and urea in groups administered with 250mg/kg leaf extract compared to the control. The result suggest no possible hepatotoxic effect and kidney malfunction after administration of 100mg/kg and 250mg/kg leaf extract. The result of the oral acute toxicity study shown that Euphobia lateriflora have oral LD50 above 5000mg/kg. ALT: Alanine aminotransferese, AST: Aspatateaminotransferese and ALP: Alkaline Phosphatese